Face it: when confronted with twenty thousand DNA matches, it's hard to place those distant relatives in their place on the family tree. Far easier to concentrate on the other, smaller category—fourth cousins or closer—for whom we have much better chances of confirming connections.
But—and there always is a caveat—since I've decided to pursue DNA cousins who share descent from my mother-in-law's fourth great-grandparents Lyman and Deidama Jackson, her proxy test volunteer (her son, my husband) must find connections with matches who are at least sixth cousins. That's where we start dipping into that larger pool of twenty thousand contestants. Facing a number like that, it's time for a DNA housecleaning.
That larger pool of possible cousins is further restricted by genetic limitations. After about the level of third cousin, some distant relatives will share no identifying genetic material at all with a percentage of their cousins. That is not to say, of course, that there is no DNA shared at all. There is a high percentage of genetic material that all human beings have in common—it's just that the selected SNPs that genealogy companies use to identify closer family connections may not include the array of items passed down from specific distant ancestors.
However, combining use of both a paper trail of documented family connections and data about distant DNA matches may still confirm a distant cousin's place in the family tree, despite sharing only a small number of centiMorgans. In such cases, what I've done is build out the lines of descent from the distant ancestor—the Jackson line in this case—then move from already-confirmed known cousins to "shared matches" identified by tools such as Ancestry's ProTools.
Of Lyman Jackson's thirteen children, there are six whose descendants are itemized in the ThruLines listing at Ancestry.com. Of course, the bulk of those matches come from John Jackson's own line, which is the line of descent leading to my mother-in-law. However, through this process I've managed to connect the majority of other ThruLines Jackson cousins to her family tree.
From that point, my next step is to take each one of those verified Jackson cousin matches and open the "Shared Matches" tab on their own entry. I then look to see how many of those connected cousins I can trace through the family tree. Sometimes, that task presents problems, but in many cases, that two-step sweep leads to discovering other Jackson descendants among those twenty thousand distant matches. And each match confirmed makes the next ones easier to place, as we place more pieces of the puzzle where they belong in the tree.
From there, it's basically "rinse and repeat" as far as I can go with that same process. Bit by bit, it opens up possibilities for where DNA matches fit in the bigger picture of a much-extended family tree.